Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
8
We explored how curcumin, a compound found in turmeric, can influence breast cancer by targeting specific cellular pathways. The study focused on understanding the role of TEAD4, a transcription factor known to affect cancer cells’ abilities to adhere and invade other tissues.
Our findings revealed that curcumin significantly decreased the migration and invasion capabilities of breast cancer cells. This was particularly important since these qualities contribute to tumor metastasis, which is the leading cause of death in breast cancer patients. In experiments with mice, curcumin also showed the potential to inhibit lung metastasis of breast cancer.
We discovered that TEAD4 promotes the expression of fibronectin, an important protein that helps cancer cells stick to each other and spread. Curcumin was found to disrupt the interaction between TEAD4 and the fibronectin gene, limiting its ability to encourage tumor spread. Interestingly, removing fibronectin from the cancer cells reversed the aggressive behavior induced by TEAD4 overexpression.
Overall, our investigation suggests that the TEAD4-fibronectin pathway could be targeted in breast cancer therapies. Curcumin demonstrates promise in reducing the aggressive nature of breast cancer and could pave the way for new treatment strategies.
Our findings revealed that curcumin significantly decreased the migration and invasion capabilities of breast cancer cells. This was particularly important since these qualities contribute to tumor metastasis, which is the leading cause of death in breast cancer patients. In experiments with mice, curcumin also showed the potential to inhibit lung metastasis of breast cancer.
We discovered that TEAD4 promotes the expression of fibronectin, an important protein that helps cancer cells stick to each other and spread. Curcumin was found to disrupt the interaction between TEAD4 and the fibronectin gene, limiting its ability to encourage tumor spread. Interestingly, removing fibronectin from the cancer cells reversed the aggressive behavior induced by TEAD4 overexpression.
Overall, our investigation suggests that the TEAD4-fibronectin pathway could be targeted in breast cancer therapies. Curcumin demonstrates promise in reducing the aggressive nature of breast cancer and could pave the way for new treatment strategies.
Read More
8
We explored the effects of curcumin, a compound derived from turmeric, on breast cancer treatment through carefully designed experiments. The study focused on enhancing curcumin's delivery and effectiveness using nanoparticles. These nanoparticles help overcome curcumin's poor solubility and low bioavailability, which can limit its anti-cancer potential.
By using a specific method to create curcumin-loaded nanoparticles, we created a formulation that helps deliver curcumin more effectively into cancer cells. When tested on BT-474 human breast cancer cells, the curcumin nanoparticles showed better cytotoxic responses compared to free curcumin. Notably, the nanoparticles demonstrated improved effectiveness when exposed to light, supporting their use in photodynamic therapy.
Overall, our findings suggest that curcumin, when enhanced through nanoparticle technology, could significantly improve treatment options for breast cancer. This study opens the door for further investigation into how turmeric and similar compounds can be maximized for therapeutic use against cancer.
By using a specific method to create curcumin-loaded nanoparticles, we created a formulation that helps deliver curcumin more effectively into cancer cells. When tested on BT-474 human breast cancer cells, the curcumin nanoparticles showed better cytotoxic responses compared to free curcumin. Notably, the nanoparticles demonstrated improved effectiveness when exposed to light, supporting their use in photodynamic therapy.
Overall, our findings suggest that curcumin, when enhanced through nanoparticle technology, could significantly improve treatment options for breast cancer. This study opens the door for further investigation into how turmeric and similar compounds can be maximized for therapeutic use against cancer.
Read More
8
Dendrosomal curcumin shows anti-cancer effects
We assessed the effects of dendrosomal curcumin (DNC), a new formulation of turmeric, on the aggressive breast cancer cell line MDA-MB231. Our investigation involved treating these cells with a specific dose of DNC and examining how it impacted their growth and survival.
Using flow cytometry, we looked at cell death rates and the cell cycle, which revealed that DNC led to significant cell death and arrested cells in a specific phase of the cell cycle. This is promising, as it suggests that DNC can effectively halt the progression of cancer cells.
Additionally, we analyzed the molecular changes caused by DNC treatment. We found that certain genes associated with cancer progression were downregulated, while others that promote apoptosis (programmed cell death) were upregulated. This indicates that DNC triggers a natural process in the cells that leads to their destruction.
The study shows that dendrosomal nanocurcumin holds considerable potential as an anti-cancer agent, offering hope for new treatment avenues in breast cancer therapy.
Using flow cytometry, we looked at cell death rates and the cell cycle, which revealed that DNC led to significant cell death and arrested cells in a specific phase of the cell cycle. This is promising, as it suggests that DNC can effectively halt the progression of cancer cells.
Additionally, we analyzed the molecular changes caused by DNC treatment. We found that certain genes associated with cancer progression were downregulated, while others that promote apoptosis (programmed cell death) were upregulated. This indicates that DNC triggers a natural process in the cells that leads to their destruction.
The study shows that dendrosomal nanocurcumin holds considerable potential as an anti-cancer agent, offering hope for new treatment avenues in breast cancer therapy.
Read More
Most Useful Reviews
9
Remission achieved
103 people found this helpful
I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I went into remission within three months, and all tumours have disappeared. I’ve been in remission for eight months with no evidence of disease.
Read More
9
Cancer prevention
1 people found this helpful
Turmeric inhibits cancer cells and helps prevent breast cancer. Its distinctive taste combats viruses and harmful bacteria, benefiting all types of inflammation, while also promoting healthy digestive function, kidney health, and appetite improvement.
Read More
6
Promising ingredient
151 people found this helpful
Curcumin is renowned for enhancing a healthy inflammatory response. Leading laboratories have proven numerous healing properties of Curcumin, prompting doctors to recommend it as an addition to traditional treatments for diseases, including breast cancer. The rich composition of turmeric also positively impacts skin condition, making it especially beneficial for women.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.2
- All Researches
9
We explored how curcumin, a compound found in turmeric, could affect triple-negative breast cancer (TNBC) by utilizing a new targeted nanoparticle delivery system. This innovative approach involves using chitosan as the carrier, targeting peptides for specificity, and curcumin itself as the therapeutic agent.
Through our research, we observed that the targeted nanoparticles effectively reduced TNBC cell growth and invasion by about 70%. Additionally, they seemed to improve the effectiveness of anti-PD-L1 treatment, enhancing survival rates by approximately 50% in both laboratory settings and animal models.
Our bioinformatics analysis revealed that curcumin plays a role in modulating tumor-associated macrophages (TAMs) by influencing important genes. Specifically, our findings suggested that curcumin could help reverse the M2 polarization state of TAMs, which is often associated with poor immune response in tumors.
Overall, our study highlights the potential of using a targeted delivery system for curcumin to overcome resistance to immunotherapy and improve outcomes in TNBC, providing a promising avenue for further research and potential new treatment options.
Through our research, we observed that the targeted nanoparticles effectively reduced TNBC cell growth and invasion by about 70%. Additionally, they seemed to improve the effectiveness of anti-PD-L1 treatment, enhancing survival rates by approximately 50% in both laboratory settings and animal models.
Our bioinformatics analysis revealed that curcumin plays a role in modulating tumor-associated macrophages (TAMs) by influencing important genes. Specifically, our findings suggested that curcumin could help reverse the M2 polarization state of TAMs, which is often associated with poor immune response in tumors.
Overall, our study highlights the potential of using a targeted delivery system for curcumin to overcome resistance to immunotherapy and improve outcomes in TNBC, providing a promising avenue for further research and potential new treatment options.
Read More
9
Curcumin enhances doxorubicin effectiveness
We observed the combined effects of curcumin, a compound from turmeric, and doxorubicin, a common chemotherapy drug, on breast cancer cells. The focus of our study was to understand how this combination impacts cell survival and triggers apoptosis, which is the process of programmed cell death.
In our experiments, we used popular breast cancer cell lines and discovered that the combination of curcumin and doxorubicin significantly increased cell death when compared to either treatment alone. As we delved into the mechanisms, we found that the duo raised levels of reactive oxygen species (ROS) within the cells. This increase led to mitochondrial changes that promoted apoptosis, as evidenced by decreased mitochondrial membrane potential and increased DNA damage.
Additionally, our in silico analysis strengthened these findings, showing a strong interaction between curcumin, doxorubicin, and key proteins related to apoptosis. The binding energies indicated a solid synergy between the compounds, suggesting that curcumin could potentially boost the effectiveness of doxorubicin in breast cancer treatment.
However, while curcumin demonstrates promise as a complementary treatment, it should be emphasized that its effects cannot be fully isolated from those of doxorubicin in the context of this study. Our findings open doors for future research but remain centered on a combined approach rather than a singular focus on curcumin alone.
In our experiments, we used popular breast cancer cell lines and discovered that the combination of curcumin and doxorubicin significantly increased cell death when compared to either treatment alone. As we delved into the mechanisms, we found that the duo raised levels of reactive oxygen species (ROS) within the cells. This increase led to mitochondrial changes that promoted apoptosis, as evidenced by decreased mitochondrial membrane potential and increased DNA damage.
Additionally, our in silico analysis strengthened these findings, showing a strong interaction between curcumin, doxorubicin, and key proteins related to apoptosis. The binding energies indicated a solid synergy between the compounds, suggesting that curcumin could potentially boost the effectiveness of doxorubicin in breast cancer treatment.
However, while curcumin demonstrates promise as a complementary treatment, it should be emphasized that its effects cannot be fully isolated from those of doxorubicin in the context of this study. Our findings open doors for future research but remain centered on a combined approach rather than a singular focus on curcumin alone.
Read More
9
We investigated the effects of combining curcumin, a natural compound from turmeric, with the chemotherapy drug sorafenib on breast cancer cells. The purpose was to see if this combination could enhance treatment effectiveness and alter the progression of breast cancer by influencing various pathways and microRNA expressions.
Through our experiments with MCF-7 breast cancer cells, we observed that the combination of curcumin, piperine, and sorafenib significantly improved the reduction of cell survival. This synergy encouraged the downregulation of certain oncomirs—miR-21 and miR-155—as well as other cancer-associated genes, while promoting the upregulation of tumor suppressor microRNAs and E-cadherin, a protein that helps prevent the spread of cancer.
Notably, we found that this treatment combination led to reduced levels of several harmful proteins involved in cancer progression and signaling, while also triggering apoptosis, or programmed cell death, and interrupting the cell cycle at specific phases.
Overall, our findings suggest that using curcumin with sorafenib may offer a promising strategy to combat breast cancer by effectively modifying critical microRNAs and signaling pathways that are essential in the disease's development and progression.
Through our experiments with MCF-7 breast cancer cells, we observed that the combination of curcumin, piperine, and sorafenib significantly improved the reduction of cell survival. This synergy encouraged the downregulation of certain oncomirs—miR-21 and miR-155—as well as other cancer-associated genes, while promoting the upregulation of tumor suppressor microRNAs and E-cadherin, a protein that helps prevent the spread of cancer.
Notably, we found that this treatment combination led to reduced levels of several harmful proteins involved in cancer progression and signaling, while also triggering apoptosis, or programmed cell death, and interrupting the cell cycle at specific phases.
Overall, our findings suggest that using curcumin with sorafenib may offer a promising strategy to combat breast cancer by effectively modifying critical microRNAs and signaling pathways that are essential in the disease's development and progression.
Read More
9
We investigated how curcumin, a compound found in turmeric, interacts with breast cancer cells, especially in the context of a new hybrid drug called CURSAHA. This innovative agent combines the effects of curcumin and Vorinostat, and we found that it effectively inhibits histone deacetylases (HDACs), which are crucial in regulating cancer cell growth.
CURSAHA not only suppresses HDAC activity but also generates reactive oxygen species (ROS) when exposed to ultrasonic waves. This ROS production contributes to its sonodynamic therapy capabilities, allowing it to target and destroy cancer cells more efficiently. We observed that CURSAHA reduces HDAC levels through redox reactions with ROS, bolstering its cancer-fighting properties.
In our tests, CURSAHA showed strong antitumor activity in laboratory settings and animal studies, suggesting it holds significant promise in breast cancer treatment. However, the combination with Vorinostat makes it challenging to assess the standalone effects of curcumin. Overall, our findings highlight CURSAHA's potential as a compelling candidate for future cancer therapies.
CURSAHA not only suppresses HDAC activity but also generates reactive oxygen species (ROS) when exposed to ultrasonic waves. This ROS production contributes to its sonodynamic therapy capabilities, allowing it to target and destroy cancer cells more efficiently. We observed that CURSAHA reduces HDAC levels through redox reactions with ROS, bolstering its cancer-fighting properties.
In our tests, CURSAHA showed strong antitumor activity in laboratory settings and animal studies, suggesting it holds significant promise in breast cancer treatment. However, the combination with Vorinostat makes it challenging to assess the standalone effects of curcumin. Overall, our findings highlight CURSAHA's potential as a compelling candidate for future cancer therapies.
Read More
9
Curcumin enhances cancer treatment efficacy
We evaluated the effectiveness of curcumin, a compound found in turmeric, in combination with another cancer drug, 5-fluorouracil (5FU), to see how they work together against breast cancer. The research focused on specially designed liposomes—tiny carriers that deliver drugs directly to cancer cells.
In our findings, we discovered that curcumin, when paired with 5FU and delivered using these liposomes, significantly reduced cell viability in MCF-7 breast cancer cells. The liposomal formulation that included RGD functionalization showed the most promising results.
This RGD-decorated liposomal form not only improved the overall effectiveness of the drugs but also enhanced the apoptosis (or cell death) rate among cancer cells. The results showed that this combination led to a notable increase in apoptosis compared to other formulations.
Overall, our work suggests that utilizing curcumin alongside 5FU in a targeted delivery system could be an effective strategy for tackling breast cancer, highlighting the potential of curcumin as part of a more powerful treatment approach.
In our findings, we discovered that curcumin, when paired with 5FU and delivered using these liposomes, significantly reduced cell viability in MCF-7 breast cancer cells. The liposomal formulation that included RGD functionalization showed the most promising results.
This RGD-decorated liposomal form not only improved the overall effectiveness of the drugs but also enhanced the apoptosis (or cell death) rate among cancer cells. The results showed that this combination led to a notable increase in apoptosis compared to other formulations.
Overall, our work suggests that utilizing curcumin alongside 5FU in a targeted delivery system could be an effective strategy for tackling breast cancer, highlighting the potential of curcumin as part of a more powerful treatment approach.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Remission achieved
103 people found this helpful
I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I went into remission within three months, and all tumours have disappeared. I’ve been in remission for eight months with no evidence of disease.
Read More
9
Cancer prevention
1 people found this helpful
Turmeric inhibits cancer cells and helps prevent breast cancer. Its distinctive taste combats viruses and harmful bacteria, benefiting all types of inflammation, while also promoting healthy digestive function, kidney health, and appetite improvement.
Read More
6
Promising ingredient
151 people found this helpful
Curcumin is renowned for enhancing a healthy inflammatory response. Leading laboratories have proven numerous healing properties of Curcumin, prompting doctors to recommend it as an addition to traditional treatments for diseases, including breast cancer. The rich composition of turmeric also positively impacts skin condition, making it especially beneficial for women.
Read More
2
No visible effect
1 people found this helpful
The drug is often recommended for cancer survivors. My mother was advised by an oncologist to take it regularly. Although I experienced no negative side effects, I did not notice any apparent effects on her breast cancer. Thus, it's challenging to assess its effectiveness.
Read More
Frequently Asked Questions
9
Remission achieved
103 people found this helpful
I have been taking 2 grams (4 capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I went into remission within three months, and all tumours have disappeared. I’ve been in remission for eight months with no evidence of disease.
2
No visible effect
1 people found this helpful
The drug is often recommended for cancer survivors. My mother was advised by an oncologist to take it regularly. Although I experienced no negative side effects, I did not notice any apparent effects on her breast cancer. Thus, it's challenging to assess its effectiveness.
9
Cancer prevention
1 people found this helpful
Turmeric inhibits cancer cells and helps prevent breast cancer. Its distinctive taste combats viruses and harmful bacteria, benefiting all types of inflammation, while also promoting healthy digestive function, kidney health, and appetite improvement.
6
Promising ingredient
151 people found this helpful
Curcumin is renowned for enhancing a healthy inflammatory response. Leading laboratories have proven numerous healing properties of Curcumin, prompting doctors to recommend it as an addition to traditional treatments for diseases, including breast cancer. The rich composition of turmeric also positively impacts skin condition, making it especially beneficial for women.
8
We explored the effects of curcumin, a compound derived from turmeric, on breast cancer treatment through carefully designed experiments. The study focused on enhancing curcumin's delivery and effectiveness using nanoparticles. These nanoparticles help overcome curcumin's poor solubility and low bioavailability, which can limit its anti-cancer potential.
By using a specific method to create curcumin-loaded nanoparticles, we created a formulation that helps deliver curcumin more effectively into cancer cells. When tested on BT-474 human breast cancer cells, the curcumin nanoparticles showed better cytotoxic responses compared to free curcumin. Notably, the nanoparticles demonstrated improved effectiveness when exposed to light, supporting their use in photodynamic therapy.
Overall, our findings suggest that curcumin, when enhanced through nanoparticle technology, could significantly improve treatment options for breast cancer. This study opens the door for further investigation into how turmeric and similar compounds can be maximized for therapeutic use against cancer.
By using a specific method to create curcumin-loaded nanoparticles, we created a formulation that helps deliver curcumin more effectively into cancer cells. When tested on BT-474 human breast cancer cells, the curcumin nanoparticles showed better cytotoxic responses compared to free curcumin. Notably, the nanoparticles demonstrated improved effectiveness when exposed to light, supporting their use in photodynamic therapy.
Overall, our findings suggest that curcumin, when enhanced through nanoparticle technology, could significantly improve treatment options for breast cancer. This study opens the door for further investigation into how turmeric and similar compounds can be maximized for therapeutic use against cancer.
9
We explored how curcumin, a compound found in turmeric, could affect triple-negative breast cancer (TNBC) by utilizing a new targeted nanoparticle delivery system. This innovative approach involves using chitosan as the carrier, targeting peptides for specificity, and curcumin itself as the therapeutic agent.
Through our research, we observed that the targeted nanoparticles effectively reduced TNBC cell growth and invasion by about 70%. Additionally, they seemed to improve the effectiveness of anti-PD-L1 treatment, enhancing survival rates by approximately 50% in both laboratory settings and animal models.
Our bioinformatics analysis revealed that curcumin plays a role in modulating tumor-associated macrophages (TAMs) by influencing important genes. Specifically, our findings suggested that curcumin could help reverse the M2 polarization state of TAMs, which is often associated with poor immune response in tumors.
Overall, our study highlights the potential of using a targeted delivery system for curcumin to overcome resistance to immunotherapy and improve outcomes in TNBC, providing a promising avenue for further research and potential new treatment options.
Through our research, we observed that the targeted nanoparticles effectively reduced TNBC cell growth and invasion by about 70%. Additionally, they seemed to improve the effectiveness of anti-PD-L1 treatment, enhancing survival rates by approximately 50% in both laboratory settings and animal models.
Our bioinformatics analysis revealed that curcumin plays a role in modulating tumor-associated macrophages (TAMs) by influencing important genes. Specifically, our findings suggested that curcumin could help reverse the M2 polarization state of TAMs, which is often associated with poor immune response in tumors.
Overall, our study highlights the potential of using a targeted delivery system for curcumin to overcome resistance to immunotherapy and improve outcomes in TNBC, providing a promising avenue for further research and potential new treatment options.
9
Curcumin enhances doxorubicin effectiveness
We observed the combined effects of curcumin, a compound from turmeric, and doxorubicin, a common chemotherapy drug, on breast cancer cells. The focus of our study was to understand how this combination impacts cell survival and triggers apoptosis, which is the process of programmed cell death.
In our experiments, we used popular breast cancer cell lines and discovered that the combination of curcumin and doxorubicin significantly increased cell death when compared to either treatment alone. As we delved into the mechanisms, we found that the duo raised levels of reactive oxygen species (ROS) within the cells. This increase led to mitochondrial changes that promoted apoptosis, as evidenced by decreased mitochondrial membrane potential and increased DNA damage.
Additionally, our in silico analysis strengthened these findings, showing a strong interaction between curcumin, doxorubicin, and key proteins related to apoptosis. The binding energies indicated a solid synergy between the compounds, suggesting that curcumin could potentially boost the effectiveness of doxorubicin in breast cancer treatment.
However, while curcumin demonstrates promise as a complementary treatment, it should be emphasized that its effects cannot be fully isolated from those of doxorubicin in the context of this study. Our findings open doors for future research but remain centered on a combined approach rather than a singular focus on curcumin alone.
In our experiments, we used popular breast cancer cell lines and discovered that the combination of curcumin and doxorubicin significantly increased cell death when compared to either treatment alone. As we delved into the mechanisms, we found that the duo raised levels of reactive oxygen species (ROS) within the cells. This increase led to mitochondrial changes that promoted apoptosis, as evidenced by decreased mitochondrial membrane potential and increased DNA damage.
Additionally, our in silico analysis strengthened these findings, showing a strong interaction between curcumin, doxorubicin, and key proteins related to apoptosis. The binding energies indicated a solid synergy between the compounds, suggesting that curcumin could potentially boost the effectiveness of doxorubicin in breast cancer treatment.
However, while curcumin demonstrates promise as a complementary treatment, it should be emphasized that its effects cannot be fully isolated from those of doxorubicin in the context of this study. Our findings open doors for future research but remain centered on a combined approach rather than a singular focus on curcumin alone.
9
We investigated the effects of combining curcumin, a natural compound from turmeric, with the chemotherapy drug sorafenib on breast cancer cells. The purpose was to see if this combination could enhance treatment effectiveness and alter the progression of breast cancer by influencing various pathways and microRNA expressions.
Through our experiments with MCF-7 breast cancer cells, we observed that the combination of curcumin, piperine, and sorafenib significantly improved the reduction of cell survival. This synergy encouraged the downregulation of certain oncomirs—miR-21 and miR-155—as well as other cancer-associated genes, while promoting the upregulation of tumor suppressor microRNAs and E-cadherin, a protein that helps prevent the spread of cancer.
Notably, we found that this treatment combination led to reduced levels of several harmful proteins involved in cancer progression and signaling, while also triggering apoptosis, or programmed cell death, and interrupting the cell cycle at specific phases.
Overall, our findings suggest that using curcumin with sorafenib may offer a promising strategy to combat breast cancer by effectively modifying critical microRNAs and signaling pathways that are essential in the disease's development and progression.
Through our experiments with MCF-7 breast cancer cells, we observed that the combination of curcumin, piperine, and sorafenib significantly improved the reduction of cell survival. This synergy encouraged the downregulation of certain oncomirs—miR-21 and miR-155—as well as other cancer-associated genes, while promoting the upregulation of tumor suppressor microRNAs and E-cadherin, a protein that helps prevent the spread of cancer.
Notably, we found that this treatment combination led to reduced levels of several harmful proteins involved in cancer progression and signaling, while also triggering apoptosis, or programmed cell death, and interrupting the cell cycle at specific phases.
Overall, our findings suggest that using curcumin with sorafenib may offer a promising strategy to combat breast cancer by effectively modifying critical microRNAs and signaling pathways that are essential in the disease's development and progression.
8
Curcumin aids liver health in treatment
We conducted a study to explore whether curcumin, a compound found in turmeric, could protect breast cancer patients from developing nonalcoholic fatty liver disease (NAFLD) while undergoing treatment with tamoxifen. This clinical trial involved 44 women diagnosed with estrogen receptor-positive breast cancer, where half received curcumin and the other half a placebo over six months.
At the end of the trial, we observed significant differences in liver health between the two groups. Only 13.6% of the patients receiving curcumin showed an increase in NAFLD grade, compared to 54.5% in the placebo group. Additionally, there was a marked decline in individuals experiencing more severe NAFLD (grade ≥ 2) among the curcumin group.
Importantly, we found no reported side effects related to the curcumin supplementation, suggesting it could be a safe additional option for women on tamoxifen. While the focus was primarily on liver health, these findings imply that curcumin may serve as a beneficial adjunct therapy, promoting overall patient well-being during breast cancer treatment. More extensive studies are necessary to confirm these promising results.
At the end of the trial, we observed significant differences in liver health between the two groups. Only 13.6% of the patients receiving curcumin showed an increase in NAFLD grade, compared to 54.5% in the placebo group. Additionally, there was a marked decline in individuals experiencing more severe NAFLD (grade ≥ 2) among the curcumin group.
Importantly, we found no reported side effects related to the curcumin supplementation, suggesting it could be a safe additional option for women on tamoxifen. While the focus was primarily on liver health, these findings imply that curcumin may serve as a beneficial adjunct therapy, promoting overall patient well-being during breast cancer treatment. More extensive studies are necessary to confirm these promising results.
References
- Zahid A, Khurshid A, Rehman SU, Hassan SMU, Akhtar R. Enhanced Intracellular Delivery of Curcumin Using Polymeric Nanocarriers: A Natural Photosensitizing Agent for Anti-Cancer Photodynamic Therapy. J Fluoresc. 2025. doi:10.1007/s10895-025-04179-0
- Dong X, Wang X, Zheng X, Jiang H, Liu L, et al. Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy. Cell Biol Toxicol. 2025;41:58. doi:10.1007/s10565-025-10001-1
- Hemati S, Mehrabinejad F, Elhaie M, Najafizade N. Curcumin Supplementation as a Preventive Strategy Against Tamoxifen-Induced Nonalcoholic Fatty Liver Disease in ER+ Breast Cancer Patients: A Triple-Blind Randomized Placebo-Controlled Trial. J Diet Suppl. 2025;22:274. doi:10.1080/19390211.2025.2465412
- Sarkar E, Kotiya A, Bhuyan R, Raza ST, Misra A, et al. Curcumin chemo-sensitizes intrinsic apoptosis through ROS-mediated mitochondrial hyperpolarization and DNA damage in breast cancer cells. Cell Signal. 2025;128:111637. doi:10.1016/j.cellsig.2025.111637
- Effat H, El Houseini ME, Abohashem RS. The Combined Impact of Curcumin: Piperine and Sorafenib on microRNAs and Different Pathways in Breast Cancer Cells. Indian J Clin Biochem. 2025;40:32. doi:10.1007/s12291-024-01212-0
- Jaberian Asl B, Afarin R, Hatami M, Dehghani Madiseh A, Roshanazadeh M, et al. Curcumin-Etoposide Synergy: Unveiling the Molecular Mechanisms of Enhanced Apoptosis and Chemoresistance Attenuation in Breast Cancer. Iran J Pharm Res. 2024;23:e150978. doi:10.5812/ijpr-150978
- Abbasi H, Hosseinkhani F, Imani Fouladi B, Tarighi S, Sadeghizadeh M, et al. Dendrosomal Curcumin Showed Cytotoxic Effects on Breast Cancer Cell Line by Inducing Mitochondrial Apoptosis Pathway and Cell Division Arrest. Iran J Pharm Res. 2024;23:e151714. doi:10.5812/ijpr-151714
- Poma P, Rigogliuso S, Labbozzetta M, Nicosia A, Costa S, et al. Epigenetic and Cellular Reprogramming of Doxorubicin-Resistant MCF-7 Cells Treated with Curcumin. Int J Mol Sci. 2024;25. doi:10.3390/ijms252413416
- Sarkar E, Khan A, Ahmad R, Misra A, Raza ST, et al. Synergistic Anticancer Efficacy of Curcumin and Doxorubicin Combination Treatment Inducing S-phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells: An In Vitro Study. Cureus. 2024;16:e75047. doi:10.7759/cureus.75047
- Lu H, Zheng J, Hu C, He J, Wang S, et al. Cyclocurcumin potently inhibits human aromatase as a potential therapeutic agent. J Steroid Biochem Mol Biol. 2025;247:106672. doi:10.1016/j.jsbmb.2024.106672
- Poma P, Massaro M, Rigogliuso S, Condorelli L, Sánchez-Espejo R, et al. Curcumin and doxorubicin encapsulated in biocompatible clay-based nanomaterial: A strategy to overcome multidrug resistance. Arch Pharm (Weinheim). 2025;358:e2400702. doi:10.1002/ardp.202400702
- Akyüz A, Şirin DY. In Silico and In Vitro Verification of the Effects of Chemotherapeutic Doxorubicin and 5-Fluorouracil in Combination With Curcumin and Vitamin C on MCF-7 Cells. J Cell Biochem. 2025;126:e30688. doi:10.1002/jcb.30688
- Rajimon KJ, Almeer R, Thangaiyan P, Khairbek A, Thomas R. In Silico Analysis of Curcumin's Targeted Cancer Therapy: Folate Receptor Pathways and Molecular Interaction Insights. Chem Biodivers. 2024. doi:10.1002/cbdv.202402561
- Lu X, Wang Z, Zhang Y, Meng T, Chen X, et al. A curcumin-based HDACs inhibitor for targeted sonodynamic therapy of breast cancer. Int J Biol Macromol. 2025;287:138616. doi:10.1016/j.ijbiomac.2024.138616
- Mahmoudi R, Mohammadi S, Mahmoudi R, Fouani MH, Ardakani MT, et al. Nanocodelivery of 5-Fluorouracil and Curcumin by RGD-Decorated Nanoliposomes Achieves Synergistic Chemotherapy for Breast Cancer. IET Nanobiotechnol. 2024;2024:4959295. doi:10.1049/nbt2/4959295
- Li M, Chen L, Wang M, Huang X, Ke Q, et al. Curcumin alleviates the aggressiveness of breast cancer through inhibiting cell adhesion mediated by TEAD4-fibronectin axis. Biochem Pharmacol. 2025;232:116690. doi:10.1016/j.bcp.2024.116690
